Nope. Never. I believe something in me just shuts my urge to have another drink off before I have too much to become ill. And I've gotten plenty hammered plenty of times, so that doesn't seem to be the case. I do know, however, that if I ever DID v* from drinking alcohol, I would not drink it again. I sure love all kinds of crazy little microbrews, so I'm hoping never to be ill from it! LOL!