I also would defiantely not reccomend it for the first few weeks until you get used to the anti-depressant, but after that MODERATION is the key. When I was on paxil I would have a couple of beers here and there and it never made me sick, but I also never pushed it...maybe 2 or 3 drinks max. It is counter-productive as alcohol is a depressant like you said. I know a lot of people on anti-depressants that enjoy a drink here and there though.