I am an emetophobe with Crohn's Disease. Unfortunately I get a lot of nausea with my disease. I was prescribed Promethazine (spelling?), but that made me very sleepy. I am a teacher and a mother of two young children, so asked my doctor if there was anything he could prescribe that wouldn't make me tired. He was reluctant to prescribe Zofran at first because he thought that was overkill. I let him know that in addition to the intestinal cramping, the nausea can be something else, and that I refused to suffer. After several complaints, he prescribed it for me. It works like a charm. I've used it when I had Crohn's attacks, regular nausea episodes, while I was in labor, and during a stomach bug. I highly recommend it.