I used to take them a few times a month, but now I haven't taken one for many months. Last time I took one was because I had food poisoning. Probably wouldn't have vomited anyways, but I felt like I might and I had REALLY severe diarrhea... Sorry tmi! lol Generally now when I feel ill or anxious I reach for something to calm the anxiety, not the nausea. I have Zofran and Compazine though, I got them prescribed for debilitating nausea on the first day of my period.