Dramamine did not work for me. I would take it in the comfort of your home and try it out. It made me more nauseated than I was before. I have been on boats and I don't really get nauseated. But I am going on a plane for the first time, REALLY SOON! I am scared I will have motion sickness. If you take anti-anxiety meds, try those! Eat lightly before the boat like crackers and water, do not starve and don't over-eat. Bring some tums along with you to suck on for nausea if you get any. Also if you can, bring ice! Chewing ice gets rid of my nausea and anxiety. Good luck to you!