They are both the same, the only difference is that Zofran is supplied by a specific company, however Odestron is the active ingredient. Its is the same if you were on the antibiotic Erythromycin, Erythromycin is the generic name of the active ingredient where as Erymax, Ethroyped is the name the company give it that still have Erythromycin as the main ingredient. Basically in answer to your question they are both the same