Quote Originally Posted by happywithoutyou View Post
I have diagnosed GI motility issues and take cyclizine daily (but still get breakthrough nausea a few times a week, although I'm finally beginning to get it under control with nortriptyline, which has been like a miracle drug for me). My understanding is that cyclizine is one of the safer antiemetics for long-term use since chemically it's essentially just an antihistamine which are pretty safe even when used very regularly. I have never been offered Zofran even when I was untreated and was so nauseous I was unable to drink water for several days at a time - in the UK I think it's pretty much exclusively reserved for chemotherapy nausea.

For what it's worth using any antiemetic long term is safer and less likely to result in dependency than using a benzodiazepine long term. Unfortunately I don't find they tend to relieve my anxiety - I still get breakthrough nausea as I said and even when I'm not nauseous I'm still having intrusive thoughts anyway. I might be a bit of a funny case though given a) I have physical stuff going on and b) I think I may be more on the OCD side than the pure phobia side anyway.
I've noticed that since my emet has been bad, the last two years, I've developed OCD too.