If nothing is working it's anxiety. Some of those meds, though they have true chemical properties can make us feel better simply through mind over matter. I took zofran everyday and i need to get more, I don't know if my doctor will give me more though. The only problem with it is you literally will not go to the bathroom for days, won't even feel like you have to. Tell yourself it works and it will. Rosary and prayer is also helpful, probably the most helpful.